Today’s Article about Sutent How it works, Uses, Side Effects, Interactions
Benefits of using this medication
Sunitinib belongs to the group of cancer-fighting medications known as antineoplastics and more specifically to a class of medications called tyrosine kinase inhibitors. These medications are antitumour medications that slow the growth of blood vessels that feed nutrients to cancer cells by disrupting cell communication. By slowing the growth of these blood vessels, sunitinib can help reduce the size of tumours, which is a collection of cancer cells.
Sunitinib is used to treat a cancer of the bowels and stomach called gastrointestinal stromal tumour (GIST) after treatment with imatinib doesn’t work. this medication can be also used to treat kidney cancer that has spread to other parts of the body, called metastatic renal cell carcinoma,and certain cancers of the pancreas called pancreatic neuroendocrine tumours (pNET) that are advanced or cannot be removed with surgery.
Your physician may have suggested this medication for conditions other than those listed in this article. If you have not discussed this with your physician or aren’t sure why you are taking this medication, talk to your physician. Do not stop taking this medication without consulting your physician.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their physician has not prescribed it.
dosage forms of medication
Each hard gelatin capsule with orange cap and body, printed in white ink “Pfizer” on the cap and “STN 12.5 mg” on the body, contains sunitinib malate equivalent to 12.5 mg of sunitinib. Nonmedicinal ingredients: croscarmellose sodium, magnesium stearate, mannitol povidone (K-25), gelatin, red iron oxide, titanium dioxide, propylene glycol, shellac, and sodium hydroxide.
Each hard gelatin capsule with caramel cap and orange body, printed with white ink “Pfizer” on the cap, “STN 25 mg” on the body, contains sunitinib malate equivalent to 25 mg of sunitinib. Nonmedicinal ingredients: croscarmellose sodium, magnesium stearate, mannitol, povidone (K-25), gelatin, red iron oxide, titanium dioxide, black iron oxide, yellow iron oxide, propylene glycol, shellac, and sodium hydroxide.
Each hard gelatin capsule with caramel cap and body, printed with white ink “Pfizer” on the cap and “STN 50 mg” on the body contains sunitinib malate equivalent to 50 mg of sunitinib. Nonmedicinal ingredients: croscarmellose sodium, magnesium stearate, mannitol povidone (K-25), gelatin, red iron oxide, titanium dioxide, black iron oxide, yellow iron oxide, propylene glycol, shellac, and sodium hydroxide.
dose of medication
The recommended dose of sunitinib to treat GIST or kidney cancer is 50 mg taken by mouth once daily for 4 weeks, followed by 2 weeks of no therapy. This 6-week cycle is then repeated.
To treat pancreatic neuroendocrine tumours the recommended dose is 37.5 mg taken by mouth once daily on the same cycle.
Daily doses should not be more than 50 mg or less than 25 mg. Sunitinib can be taken with or without food. Do not take sunitinib with grapefruit juice, since this may interact with sunitinib and increase the amount of sunitinib in your blood.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your physician has recommended a dose different from the ones listed here, don’t change the way that you are taking the medication without consulting your physician.
It is important to take this medication exactly as prescribed by your physician. in case of missed dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you aren’t sure what to do after missing a dose, contact your physician or pharmacist for advice.
Store this medication at room temperature (between 15°C to 30°C) and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Contraindications to the use of the medication
Do not use sunitinib if you:
- are allergic to sunitinib or any ingredients of the medication
- are pregnant
side effects of the medication
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below aren’t experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your physician.
These symptoms may occur in some patients and in this case, you should refer to your consultant. But the majority of the patients don’t suffer from any side effects, so do not stop using the medicine because of fear of in listed side effect . , .
Contact your physician if you experience these side effects and intolerable. Your pharmacist may be able to advise you on managing side effects.
- abdominal pain
- changes in sensation of taste
- dry mouth
- dry skin
- hair colour change
- heartburn or indigestion
- loss of appetite
- mouth pain, irritation, or sores
- muscle or joint pain
- rash or blisters on the palms of hands or soles of feet
- skin colour change (yellow)
- upset stomach
Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you don’t seek medical attention.
Check with your physician as soon as possible if any of the following side effects occur:
- bone pain or bone damage
- increased blood pressure
- painful skin ulcers
- signs of a blood clot (e.g., sudden chest pain, shortness of breath, sudden leg pain, leg swelling, or leg redness)
- signs of an infection (e.g., fever, flu-like symptoms, fatigue, weakness)
- signs of heart failure (e.g., feet or ankle swelling, fatigue when doing regular household activities, shortness of breath)
- signs of heart rhythm irregularity (e.g., dizziness, palpitations, fainting, feeling of rapid, pounding heartbeat)
- signs of kidney failure (e.g., decreased urine production, swelling, fatigue, abdominal pain)
- signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
- skin ulcers
- symptoms of low blood sugar (e.g., cold sweat, cool pale skin, headache, fast heart beat, weakness)
- signs of decreased thyroid function (e.g., dry skin, constipation, weight gain, fatigue)
- unexplained bleeding (e.g., nosebleeds, darkened urine, unusual bruising or bleeding)
- unexplained muscle aches or weakness or dark colored urine
Stop taking the medication and seek immediate medical attention if any of the following occur:
- signs of a serious allergic reaction (e.g., swelling of face or throat, hives, or difficulty breathing)
- signs of bleeding in the stomach (e.g., bloody, black, or tarry stools, spitting up of blood, vomiting blood or material that looks like coffee grounds)
- signs of a heart attack (e.g., chest pain or pressure, pain extending through shoulder and arm, nausea and vomiting, sweating)
- signs of pancreatitis (e.g., abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, swollen abdomen)
- signs of reversible posterior leukoencephalopathy syndrome (e.g., headache, seizures, tiredness, confusion, vision changes)
- signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort
- signs of stroke (e.g., sudden or severe headache; sudden loss of coordination; vision changes; sudden slurring of speech; or unexplained weakness, numbness, or pain in arm or leg)
Some people may experience side effects other than those listed. Check with your physician if you notice any symptom that worries you while you are taking this medication.
precautions of the medication
Before you start taking a medication, be sure to inform your physician of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take this medication.
Abnormal heart rhythms: This medication can cause abnormal heart rhythms, which often have no symptoms. Certain medications (e.g., sotalol, quinidine, thioridazine, chlorpromazine, droperidol, pimozide, moxifloxacin, mefloquine, pentamidine, arsenic trioxide, probucol, tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation, and should not be used in combination with sunitinib. You are more at risk for this type of abnormal heart rhythm and its complications if you:
- are female
- are older than 65 years of age
- have a family history of sudden cardiac death
- have a history of heart disease or abnormal heart rhythms
- have a slow heart rate
- have congenital prolongation of the QT interval
- have diabetes
- have had a stroke
- have low potassium, magnesium, or calcium levels
- have nutritional deficiencies
If you have heart disease and abnormal heart rhythms, or people are taking certain medications (e.g., verapamil, atazanavir), discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Adrenal gland problems: Adrenal glands produce chemical messengers that are responsible for the normal function of the body’s organs, including how your body responds to injury or stress. On rare occasions, sunitinib may cause your adrenal gland to function improperly. Your physician may monitor your adrenal gland condition especially if you have experienced stress such as surgery, injury, or severe infection.
Bleeding: Sunitinib may increase your risk of bleeding. On rare occasions, tumour bleeding has occurred. If you experience signs of bleeding (e.g., nosebleeds, darkened urine or stools), contact your physician as soon as possible. Your physician will perform regular blood tests to monitor you while you are taking this medication.
Blood cell counts: This medication may decrease the number of blood cells in your body. Your physician will perform a blood test regularly to monitor your blood cell count while you are taking sunitinib.
Blood clots: Sunitinib may cause blood clots in the legs (deep vein thrombosis) to form that can move to the lungs (pulmonary embolism), heart (heart attack) or brain (stroke).
If you have a history of clotting you may be at increased risk of experiencing blood clot-related problems such as heart attack, stroke, or clots in the deep veins of your leg. Discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. If you experience symptoms such as sharp pain and swelling in the leg, difficulty breathing, chest pain, blurred vision or difficulty speaking, seek immediate medical attention.
Blood glucose: Sunitinib can cause large decreases in glucose levels in the blood. This can happen even if you don’t have diabetes. People with diabetes may find it necessary to monitor their blood sugar more frequently while using this medication. Changes to your medications may become necessary. If you experience symptoms of decreased blood sugar, such as cold sweats, cool, pale skin, headache, rapid heartbeat or unusual weakness, talk to your physician. If you experience symptoms of dangerously low blood glucose, such as seizures, delirium, or loss of consciousness, this is a medical emergency and requires immediate medical attention.
High blood pressure: Your physician may check your blood pressure before starting sunitinib and then ask you to measure your blood pressure regularly while taking sunitinib. Some people taking sunitinib develop very high blood pressure that requires adding blood pressure medications, changing the sunitinib dose, or even stopping the medication for a period of time. Talk to your physician if you have any concerns.
Heart problems: This medication can decrease heart function, which may lead to heart failure. If you experience symptoms of heart failure such as unusual tiredness, shortness of breath, or swelling of the feet and ankles, contact your physician.
If you have a history of decreased heart function (i.e., heart arrhythmias, congestive heart failure such as left ventricular dysfunction, heart attack, heart bypass surgery), discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Jaw problems: On rare occasions, sunitinib may cause severe jaw problems, especially in people who have had invasive dental procedures or are taking bisphosphonates (e.g., alendronate, risedronate). If you experience any pain in the jaw, contact your physician immediately. Invasive dental procedures should be avoided if possible.
Kidney function: This medication can cause decreased kidney function or kidney failure. If you experience puffy hands, face or feet, high blood pressure, unusual muscle cramping, or darkened urine, this medication may be affecting how well your kidneys are working. If you notice any of these symptoms, contact your physician as soon as possible.
Liver function: This medication may cause a decrease in liver function. Sunitinib has also been reported to cause liver failure, which has in some cases caused death. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your physician immediately.
Your physician may want to test your liver function regularly with blood tests while you are taking this medication. This often allows reduced liver function to be identified before it becomes too severe.
Male contraception: Sunitinib can cause harm to the fetus if the female partner of a man taking sunitinib becomes pregnant. Men should use effective contraception while taking sunitinib.
Muscle problems: On rare occasions, people have had severe muscle problems while taking sunitinib. If you have muscle aches or weakness, or dark-coloured urine, contact your physician as soon as possible.
Pancreatitis: Sunitinib can cause the pancreas to become inflamed. If you have a history of pancreatitis, discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Report signs of pancreatitis such as abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, or swollen abdomen to your physician immediately.
Reversible posterior leukoencephalopathy syndrome (RPLS): This is a rare disease of the brain that may occur when using medications like sunitinib. If you have had a previous episode of RPLS, sunitinib may not be an appropriate medication for you. Make sure your physician knows you have experienced this before. If you experience signs and symptoms of RPLS, such as headache, seizures, change in awareness or consciousness, or vision changes, contact your physician immediately.
Seizures: Rarely, there have been cases of people having seizures while taking sunitinib. If you have a history of seizures or seizure disorders, discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Thyroid problems: Sunitinib may decrease thyroid hormone levels. If you have symptoms of low thyroid such as dry skin, constipation, weight gain, or fatigue, go see your physician.
Tumour lysis syndrome: Sunitinib, like many other cancer medications, causes many cancer cells to be suddenly killed when treatment is first started. This can overwhelm the body with waste products from the cells. As a result, the body may not be able to keep up with getting rid of all the waste. When this happens, you may experience nausea, shortness of breath, cloudy urine, or joint pain. This is called tumour lysis syndrome. Your physician may prescribe some medications to help your body get rid of the waste products. Make sure you understand how to use these medications and report any of these signs or symptoms to your physician immediately.
Pregnancy: This medication should not be used during pregnancy. If you become pregnant while taking this medication, contact your physician immediately.
Breast-feeding: It isn’t known if sunitinib passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your physician about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children.
Drug-Drug interaction of the medication
There may be an interaction between sunitinib and any of the following:
- abiraterone acetate
- androgens (e.g., methyltestosterone, nandrolone, testosterone)
- antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
- “azole” antifungals (e.g., itraconazole, ketoconazole, voriconazole)
- bacillus Calmette-Guérin (BCG)
- bisphosphonates (e.g., alendronate, etidronate)
- calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
- cancer medications (e.g., carboplatin, cyclophosphamide, doxorubicin, ifosfamide, vincristine)
- diabetes medications (e.g., chlorpropamide, glipizide, glyburide, insulin, metformin, nateglinide, rosiglitazone)
- estrogens (e.g., conjugated estrogen, estradiol, ethinyl estradiol)
- “gliptin” diabetes medications (e.g., linagliptin, saxagliptin, sitagliptin)
- grapefruit juice
- HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delaviridine, efavirenz, etravirine, nevirapine)
- HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
- macrolide antibiotics (e.g., clarithromycin, erythromycin)
- monoamine oxidase inhibitors (MAOIs; e.g., moclobemide, rasagiline, selegiline, tranylcypromine)
- protein kinase inhibitors (e.g., bosutinib, dabrafenib, imatinib)
- quinolone antibiotics (e.g., ciprofloxacin, ofloxacin, sparfloxacin)
- St. John’s wort
- selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, duloxetine, fluoxetine, paroxetine, sertraline)
- serotonin antagonists (anti-emetic medications; e.g., granisetron, ondansetron)
- somatostatin acetate
- “statin” anti-cholesterol medications (e.g., atorvastatin, lovastatin, simvastatin)
- sulfonamide antibiotics (“sulfas”; e.g., sulfisoxazole, sulfamethoxazole)
If you are taking any of these medications, talk to your physician or pharmacist. Depending on your specific circumstances, your physician may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications doesn’t always mean that you must stop taking one of them. talk to your physician about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your physician or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Terms and Definitions used in this article:
side effects: The drug side effects are monitored by Clinical Trials and studies that are regularly published in scientific journals and medical conferences.
- If an adverse effect occurred during a clinical trial, whether it was relevant or irrelevant to the drug. It should be registered as a side effect.
- The medicine is not registered for use if the side-effects are dangerous or life-threating, and the approval of drug release to the Market is regulated by the World Health Organization WHO, the Food and Drug Administration of the United States FDA, EMEA and other national ministry of health.
- These symptoms may occur in some patients and in this case, you should refer to your consultant. But the majority of the patients don’t suffer from any side effects, so do not stop using the medicine because of fear of in listed side effect
Contraindications to the use of the drug:
contraindication is a condition or factor that serves as a reason to withhold a certain medical treatment due to the harm that it would cause the patient. Contraindication is the opposite of indication, which is a reason to use a certain treatment.
Therefore, you must inform your doctor of all the diseases that you suffer from and your health history in order not to be affected negatively by the use of a particular medicine and please do not stop using the medication by yourself without referring to a doctor
is a change in the action or side effects of a drug caused by concomitant administration with a food, beverage, supplement, or another drug.
There are many causes of drug interactions. For example, one drug may alter the pharmacokinetics of another. Alternatively, drug interactions may result from competition for a single receptor or signaling pathway.
- US National Library of Medicine, National Institutes of Health
- Centers for Disease Control and Prevention
- The FDA‘s website
- WHO‘s website
we finished our discussion today’s article entitled Sutent How it works, Uses, Side Effects, Interactions
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