Frova How it works, Uses, Side Effects, Interactions
Today’s Article about Frova How it works, Uses, Side Effects, Interactions
Benefits of using this medication
Frovatriptan belongs to a class of medications known as 5-hydroxytryptamine agonists (also called triptans). It is used to treat migraine headaches with or without aura (warning signs that occur prior to the onset of a migraine) in adults. The pain of migraine headaches is thought to be caused by dilated blood vessels inside the head. Frovatriptan relieves migraine headaches by constricting these blood vessels.
Frovatriptan isn’t recommended for other types of headache or for headache prevention.
Your physician may have suggested this medication for conditions other than those listed in this article. If you have not discussed this with your physician or aren’t sure why you are taking this medication, talk to your physician. Do not stop taking this medication without consulting your physician.
dosage forms of medication
Each round, white, film-coated tablet, debossed with “2.5” on one side and “E” on the other side, contains 2.5 mg of frovatriptan (base) as the succinate. Nonmedicinal ingredients: colloidal silicon dioxide NF, hydroxypropylmethylcellulose USP, lactose NF, magnesium stearate NF, microcrystalline cellulose NF, polyethylene glycol 3000 USP, sodium starch glycollate NF, triacetin USP, titanium dioxide USP, and triacetin USP.
dose of medication
The recommended adult dose of frovatriptan is 2.5 mg taken by mouth with fluids for migraine headache with or without aura. If the headache goes away with the first dose but then returns, a second dose of 2.5 mg may be taken between 4 and 24 hours after the first. You should never take more than 2 tablets in a 24-hour period.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your physician has recommended a dose different from the ones listed here, don’t change the way that you are taking the medication without consulting your physician.
If you don’t have relief from the headache with the first dose of medication, it is unlikely that a second dose will help.
It is important to take this medication exactly as prescribed by your physician.
Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Contraindications to the use of the medication
Do not take this medication if you:
- are allergic to frovatriptan or any ingredients of the medication
- don’t have a clear diagnosis of migraine
- have angina (chest pain), including Prinzmetal’s angina (coronary vasospasm)
- have blood vessel disease (e.g., ischemic bowel disease, Raynaud’s syndrome, stroke, transient ischemic attacks (TIAs))
- have certain types of migraine headaches (including hemiplegic, basilar, or ophthalmoplegic migraine)
- have had a heart attack
- have heart disease (e.g., heart valve disease, ischemic heart disease, abnormal heart rhythms, congenital heart disease)
- have high blood pressure that is severe or not under control
- have severely reduced liver function
- have taken another 5-hydroxytryptamine agonist (i.e., naratriptan, rizatriptan, zolmitriptan) in the previous 24 hours
- have taken ergotamine-containing or ergot-type medications (such as dihydroergotamine, ergotamine, or methysergide) in the previous 24 hours
side effects of the medication
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below aren’t experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your physician.
These symptoms may occur in some patients and in this case, you should refer to your consultant. But the majority of the patients don’t suffer from any side effects, so do not stop using the medicine because of fear of in listed side effect . , .
Contact your physician if you experience these side effects and intolerable. Your pharmacist may be able to advise you on managing side effects.
- decreased sensation of touch
- dry mouth
- feelings of (in any part of the body):
- headache (other than migraine)
- muscle aches or weakness
Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you don’t seek medical attention.
Check with your physician as soon as possible if any of the following side effects occur:
- increased blood pressure
- skin rash, hives, itching, or bumps on skin
- slow, fast, or pounding heartbeat
- vision changes (usually temporary)
Stop taking the medication and seek immediate medical attention if any of the following occur:
- convulsions (seizures)
- heart attack (symptoms include pain, pressure, tightness, or heaviness in the chest, jaw, neck or shoulder, sweating, or shortness of breath)
- lower abdominal pain or severe rectal bleeding (blood in the stool or black, tarry stools)
- severe allergic reaction (symptoms include: swelling of the face or throat, hives, difficulty breathing)
- stroke (symptoms include: sudden numbness or weakness, especially on one side of the body; sudden confusion or problems with speech; sudden vision problems in one or both eyes; sudden dizziness or loss of coordination; sudden severe headache, especially if it seems different from your usual headaches)
Some people may experience side effects other than those listed. Check with your physician if you notice any symptom that worries you while you are taking this medication.
precautions of the medication
Before you start taking a medication, be sure to inform your physician of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take this medication.
Allergy: People allergic to other medications in this class (5-hydroxytryptamine agonists such as rizatriptan and naratriptan) can also have an allergic reaction to frovatriptan. If you are allergic to any of these medications, you should not take frovatriptan unless advised to do so by your physician.
Blood pressure: Frovatriptan may cause an increase in blood pressure. If you have high blood pressure, discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. People with severe or uncontrolled high blood pressure should not take frovatriptan.
Drowsiness/reduced alertness: This medication may cause drowsiness. Do not drive, operate machinery, or perform other potentially hazardous tasks until you have determined how this medication affects you.
Heart disease and stroke: This medication may cause narrowing of the blood vessels that supply the heart. This can lead to chest pain, heart attacks, arrhythmias (irregular heartbeat), and other heart problems. There have also been reports of bleeding in the brain and stroke with this medication. For this reason, frovatriptan should not be used by people with heart or blood vessel disease. If you have certain risk factors for heart disease (e.g., high blood pressure, high cholesterol, smoking, obesity, diabetes, family history of coronary artery disease, menopause, men over 40 years of age), tell your physician.
Medication overuse headaches: As with other medications used to treat headache pain, taking frovatriptan too frequently may cause headaches to recur as the medication wears off. If you find that headaches return frequently, you may be taking too much of this medication. This situation should be discussed with your physician.
Seizures: If you have seizures or a history of seizure disorder, discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Serotonin syndrome: This medication may cause a rare but potentially life-threatening condition called serotonin syndrome, especially when used with other medications that increase serotonin levels (e.g., sumatriptan, rizatriptan, certain antidepressants, St. John’s wort, sibutramine, venlafaxine). If you experience symptoms such as agitation, confusion, hallucinations, fast heart rate, fever, lack of coordination, increased body temperature, overactive reflexes, nausea, vomiting, and diarrhea, get immediate medical attention.
Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your physician immediately.
Breast-feeding: It isn’t known if frovatriptan passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your physician about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children less than 18 years of age.
Seniors: There is limited experience with the use of frovatriptan by people over 65 years of age. The use of this medication by seniors isn’t recommended.
Drug-Drug interaction of the medication
There may be an interaction between frovatriptan and any of the following:
- amphetamines (e.g., dextroamphetamine, lisdexamphetamine)
- antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzepine, quetiapine, risperidone)
- ergot-containing medications (e.g., dihydroergotamine, ergotamine, or methysergide), if taken at the same time or within the previous 24 hours
- monoamine oxidase inhibitors (MAOIs; e.g., maprotiline, moclobemide, selegiline, tranylcypromine)
- narcotic pain relievers (e.g., codeine, fentanyl, morphine, oxycodone)
- other 5-hydroxytryptamine agonists (e.g., rizatriptan, naratriptan, zolmitriptan) if taken at the same time or within the previous 24 hours
- St. John’s wort
- serotonin/norepinephrine reuptake inhibitors (SNRIs; e.g., desvenlafaxine, duloxetine, venlafaxine)
- selective serotonin reuptake inhibitors (SSRIs; e.g., paroxetine, fluoxetine, sertraline, fluvoxamine)
- serotonin antagonists (anti-emetic medications; e.g., granisetron, ondansetron)
- tricyclic antidepressants (e.g., amitriptyline, desipramine, imipramine)
If you are taking any of these medications, talk to your physician or pharmacist. Depending on your specific circumstances, your physician may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications doesn’t always mean that you must stop taking one of them. talk to your physician about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your physician or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Terms and Definitions used in this article:
side effects: The drug side effects are monitored by Clinical Trials and studies that are regularly published in scientific journals and medical conferences.
- If an adverse effect occurred during a clinical trial, whether it was relevant or irrelevant to the drug. It should be registered as a side effect.
- The medicine is not registered for use if the side-effects are dangerous or life-threating, and the approval of drug release to the Market is regulated by the World Health Organization WHO, the Food and Drug Administration of the United States FDA, EMEA and other national ministry of health.
- These symptoms may occur in some patients and in this case, you should refer to your consultant. But the majority of the patients don’t suffer from any side effects, so do not stop using the medicine because of fear of in listed side effect
Contraindications to the use of the drug:
contraindication is a condition or factor that serves as a reason to withhold a certain medical treatment due to the harm that it would cause the patient. Contraindication is the opposite of indication, which is a reason to use a certain treatment.
Therefore, you must inform your doctor of all the diseases that you suffer from and your health history in order not to be affected negatively by the use of a particular medicine and please do not stop using the medication by yourself without referring to a doctor
is a change in the action or side effects of a drug caused by concomitant administration with a food, beverage, supplement, or another drug.
There are many causes of drug interactions. For example, one drug may alter the pharmacokinetics of another. Alternatively, drug interactions may result from competition for a single receptor or signaling pathway.
- US National Library of Medicine, National Institutes of Health
- Centers for Disease Control and Prevention
- The FDA‘s website
- WHO‘s website
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