Today’s Article about Fasenra How it works, Uses, Side Effects, Interactions
Benefits of using this medication
Benralizumab is classified as monoclonal antibodies. Specifically, it is an interleukin-5 inhibitor. It is used in addition to other medication to treat the symptoms of a type of asthma called eosinophilic asthma. This medication may be used when other “preventer” asthma medications, such as long-acting bronchodilators and corticosteroids have not been effective.
Symptoms of asthma are caused by inflammation in the airways. This inflammation is caused by a number of different cells and chemicals produced by the body. Eosinophils are a type of white blood cell that are believed to contribute to the inflammation. Eosinophilic asthma is a type of asthma in which there is an increased number of eosinophils in the lungs or blood.
This medication may be available under several brands and/or in several different dosage forms. Any brand name of this medication may not be available in all of the dosage forms or approved for all of the conditions discussed in this article. As well, some forms of this medication may not be used for all of the conditions discussed in this article.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their physician has not prescribed it.
dosage forms of medication
Each 1 mL of preservative-free, sterile aqueous solution for injection contains 30 mg of benralizumab. Nonmedicinal ingredients: L-histidine, L-histidine hydrochloride monohydrate, α,α-trehalose dehydrate, polysorbate 20, and water for injection.
dose of medication
The recommended dose of benralizumab is 30 mg injected subcutaneously (under the skin) into the upper arm, thigh or abdomen. The first three doses are injected once every 4 weeks. After this, the medication is injected once every 8 weeks.
Benralizumab is always given under the supervision of a physician in a hospital or similar setting with access to sterile equipment for preparation and the medical training to manage side effects, such as a severe allergic reaction.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your physician has recommended a dose different from the ones listed here, don’t change the way that you are taking the medication without consulting your physician.
It is important this medication be given exactly as recommended by your physician. If you miss an appointment to receive benralizumab, contact your physician as soon as possible to reschedule your appointment.
This medication should be kept refrigerated in its original package to protect it from light. Do not shake or freeze this medication. Keep it out of the sight and reach of children. Benralizumab may be removed from the refrigerator 30 minutes prior to injection to allow it to warm to room temperature.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Contraindications to the use of the medication
Do not take this medication if you are allergic to benralizumab or any ingredients of the medication.
side effects of the medication
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below aren’t experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your physician.
These symptoms may occur in some patients and in this case, you should refer to your consultant. But the majority of the patients don’t suffer from any side effects, so do not stop using the medicine because of fear of in listed side effect . , .
Contact your physician if you experience these side effects and intolerable. Your pharmacist may be able to advise you on managing side effects.
- reaction at the injection site (e.g., redness, swelling, pain)
- sore throat
Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you don’t seek medical attention.
Check with your physician as soon as possible if any of the following side effects occur:
- abdominal pain or discomfort
- skin rash, redness, itching or swelling
- trouble breathing
Stop taking the medication and seek immediate medical attention if any of the following occur:
- signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
Some people may experience side effects other than those listed. Check with your physician if you notice any symptom that worries you while you are taking this medication.
precautions of the medication
Before you start using a medication, be sure to inform your physician of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Acute asthma attacks: Benralizumab isn’t intended to treat an acute asthma attack. If you start developing asthma symptoms, be sure to use your reliever medication for rapid relief of your asthma symptoms. It is very important that you have your reliever medication with you at all times. If you experience worsening symptoms or your reliever medications aren’t as effective as usual, contact your physician or seek medical attention immediately.
Allergic reactions: In rare cases, some people may develop a serious allergic reaction to this medication. These reactions usually occur within hours of receiving the medication, but may occur after several days. Signs of an allergic reaction include a severe rash, hives, swollen face or throat, or difficulty breathing. If these occur, let your physician or nurse know immediately.
Infection: This medication may prevent successful treatment of certain types of parasite infections. If you have a history of infection by intestinal worms, such as tapeworm, discuss with your physician discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Pregnancy: No studies have been done to determine the safety and effectiveness of this medication when used by women who are pregnant. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your physician immediately.
Women who want to become pregnant should stop using this medication for at least 4 months before trying to conceive.
Breast-feeding: It isn’t known if benralizumab passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your physician about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children.
Drug-Drug interaction of the medication
Tell your physician or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them. Depending on your specific circumstances, your physician may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications doesn’t always mean that you must stop taking one of them. talk to your physician about how any drug interactions are being managed or should be managed.
Terms and Definitions used in this article:
side effects: The drug side effects are monitored by Clinical Trials and studies that are regularly published in scientific journals and medical conferences.
- If an adverse effect occurred during a clinical trial, whether it was relevant or irrelevant to the drug. It should be registered as a side effect.
- The medicine is not registered for use if the side-effects are dangerous or life-threating, and the approval of drug release to the Market is regulated by the World Health Organization WHO, the Food and Drug Administration of the United States FDA, EMEA and other national ministry of health.
- These symptoms may occur in some patients and in this case, you should refer to your consultant. But the majority of the patients don’t suffer from any side effects, so do not stop using the medicine because of fear of in listed side effect
Contraindications to the use of the drug:
contraindication is a condition or factor that serves as a reason to withhold a certain medical treatment due to the harm that it would cause the patient. Contraindication is the opposite of indication, which is a reason to use a certain treatment.
Therefore, you must inform your doctor of all the diseases that you suffer from and your health history in order not to be affected negatively by the use of a particular medicine and please do not stop using the medication by yourself without referring to a doctor
is a change in the action or side effects of a drug caused by concomitant administration with a food, beverage, supplement, or another drug.
There are many causes of drug interactions. For example, one drug may alter the pharmacokinetics of another. Alternatively, drug interactions may result from competition for a single receptor or signaling pathway.
- US National Library of Medicine, National Institutes of Health
- Centers for Disease Control and Prevention
- The FDA‘s website
- WHO‘s website
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