Benefits of using this medication

This combination product contains two medications: azilsartan and chlorthalidone. Azilsartan is classified as angiotensin II receptor blockers (ARBs). Chlorthalidone is classified as diuretics, or water pills. Both medications work in the kidney to reduce severe high blood pressure. This medication works to lower blood pressure within 1 to 2 weeks.

This medication may be available under several brands and/or in several different dosage forms. Any brand name of this medication may not be available in all of the dosage forms or approved for all of the conditions discussed in this article. As well, some forms of this medication may not be used for all of the conditions discussed in this article.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their physician has not prescribed it.

dosage forms of medication

40 mg/12.5 mg
Each pale red, round, biconvex, film-coated tablet imprinted with “A/C” and “40/12.5” on one side contains 42.68 mg of azilsartan medoxomil potassium (equivalent to 40 mg of azilsartan) and 12.5 mg of chlorthalidone. Nonmedicinal ingredients: mannitol, microcrystalline cellulose, fumaric acid, sodium hydroxide, hydroxypropyl cellulose, crospovidone, magnesium stearate, hypromellose 2910, talc, titanium dioxide, ferric oxide red, polyethylene glycol 8000, and printing ink grey.

80 mg/12.5 mg
Each pale red, round, biconvex, film-coated tablet imprinted with “A/C” and “80/12.5” on one side contains 85.36 mg of azilsartan medoxomil potassium (equivalent to 80 mg of azilsartan) and 12.5 mg of chlorthalidone. Nonmedicinal ingredients: mannitol, microcrystalline cellulose, fumaric acid, sodium hydroxide, hydroxypropyl cellulose, crospovidone, magnesium stearate, hypromellose 2910, talc, titanium dioxide, ferric oxide red, polyethylene glycol 8000, and printing ink grey.

40 mg/25 mg
Each light red, round, biconvex, film-coated tablet imprinted with “A/C” and “40/25” on one side contains 42.68 mg of azilsartan medoxomil potassium (equivalent to 40 mg of azilsartan) and 25 mg of chlorthalidone. Nonmedicinal ingredients: mannitol, microcrystalline cellulose, fumaric acid, sodium hydroxide, hydroxypropyl cellulose, crospovidone, magnesium stearate, hypromellose 2910, talc, titanium dioxide, ferric oxide red, polyethylene glycol 8000, and printing ink grey.

dose of medication

The usual adult starting dose of azilsartan – chlorthalidone is 40 mg of azilsartan, with 12.5 mg of chlorthalidone (40 mg/12.5 mg). This is taken once daily at the same time every day. Azilsartan-chlorthalidone may be taken with food or on an empty stomach.

After 2 to 4 weeks, your physician may increase the dose, depending on how well the medication works for you.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your physician has recommended a dose different from the ones listed here, don’t change the way that you are taking the medication without consulting your physician.

It is important to take this medication exactly as prescribed by your physician. Continue to take the medication, even if you feel that it isn’t helping very much. High blood pressure doesn’t have symptoms, so it can be hard for you to know if the medication is working.

in case of missed dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you aren’t sure what to do after missing a dose, contact your physician or pharmacist for advice.

Store this medication in its original container at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Contraindications to the use of the medication

Do not take azilsartan-chlorthalidone if you:

  • are allergic to azilsartan, chlorthalidone, or any ingredients of the medication
  • are allergic to sulfonamide medications (sulfa drugs)
  • are breast-feeding
  • are or are planning to become pregnant
  • are producing very little urine
  • are taking aliskiren and have diabetes or decreased kidney function
  • have a low level of sodium in your blood that has not responded to treatment
  • have difficulty urinating

side effects of the medication

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below aren’t experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your physician.

These symptoms may occur in some patients and in this case, you should refer to your consultant. But the majority of the patients don’t suffer from any side effects, so do not stop using the medicine because of fear of in listed side effect . , .

Contact your physician if you experience these side effects and intolerable. Your pharmacist may be able to advise you on managing side effects.

  • back or leg pain
  • constipation
  • decreased appetite
  • decreased ability or interest in sexual activity
  • diarrhea
  • difficulty sleeping
  • dizziness
  • drowsiness
  • fatigue
  • headache
  • increased sensitivity to the sun – more likely to sunburn
  • muscle cramps or spasms
  • nausea
  • restlessness trouble sleeping
  • upset stomach
  • vomiting

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you don’t seek medical attention.

Check with your physician as soon as possible if any of the following side effects occur:

  • increased heart rate or irregular heart beat
  • pins and needles feeling in your fingers
  • signs of anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
  • signs of bleeding (e.g., nosebleeds, blood in urine, coughing blood, bleeding gums, unusual bruising or bleeding)
  • signs of electrolyte imbalance (e.g., muscle pain or cramps, weakness, irregular heart beat)
  • signs of infection (symptoms may include fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
  • signs of kidney problems (e.g., changed frequency of urination, nausea, vomiting, swelling of hands, feet)
  • signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
  • signs of low blood pressure (e.g., dizziness when rising from sitting or lying, fainting)
  • signs of muscle damage (e.g., unexplained muscle pain, tenderness or weakness, or brown or discoloured urine)
  • signs of pancreatitis (e.g., abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, swollen abdomen)
  • swollen glands in the mouth and neck
  • symptoms of high blood sugar (e.g., frequent urination, increased thirst, excessive eating, unexplained weight loss, poor wound healing, infections, fruity breath odour)

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
  • signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort
  • symptoms of eye problems (e.g., eye pain, blurred vision, sudden nearsightedness)

Some people may experience side effects other than those listed. Check with your physician if you notice any symptom that worries you while you are taking this medication.

precautions of the medication

Before you start using a medication, be sure to inform your physician of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Allergy: Some people who are allergic to sulfa antibiotics (sulfonamides) also experience allergic reactions to chlorthalidone. Before you take azilsartan-chlorthalidone, inform your physician about any previous adverse reactions you have had to medications, especially sulfa antibiotics. Contact your physician at once if you experience signs of an allergic reaction, such as skin rash, itching, difficulty breathing or swelling of the face and throat.

Drowsiness/reduced alertness: Azilsartan-chlorthalidone may cause drowsiness or dizziness, affecting mental and physical abilities needed to drive or operate machinery. Avoid these and other hazardous tasks until you have determined how this medication affects you.

Fluid and electrolyte balance: Azilsartan-chlorthalidone may cause the levels of electrolytes such as potassium, sodium, magnesium, chloride, and calcium in the blood to change while taking this medication. If you experience symptoms of fluid and electrolyte imbalance such as muscle pains or cramps; dry mouth; numb hands, feet, or lips; or racing heartbeat, contact your physician as soon as possible. Your physician will do blood tests regularly to monitor the levels of these electrolytes in your blood while you are taking this medication. Do not use potassium supplements or salt substitutes with potassium unless recommended by your physician.

Gout: Chlorthalidone, like other diuretics, may increase the level of uric acid in the body. If you develop painful, warm, and swollen joints or difficulty with urination, contact your physician as soon as possible.

If you have a history of gout, discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Kidney function: The use of azilsartan may affect the function of the kidneys, especially for those who already have kidney problems. Certain people have experienced changes in kidney function (e.g., people with narrowed blood vessels in their kidneys, diabetes, or severe congestive heart failure). The use of other diuretics (water pills), nonsteroidal anti-inflammatory drugs (NSAIDs), or aliskiren may further increase risk of kidney problems for people already at risk for this problem. If you have kidney disease or reduced kidney function, discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

This medication should not be taken by people with severely decreased kidney function.

Liver function: If you have liver disease or reduced liver function, discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. This medication isn’t recommended for people with severely reduced liver function.

Low blood pressure: Some people taking azilsartan-chlorthalidone may experience sudden blood pressure drops when getting up from a sitting or lying position. These blood pressure drops could lead to dizziness, lightheadedness, and falls. Low blood pressure is more likely to occur if you are dehydrated, are taking additional diuretics (“water pills”), are on a low-salt diet, or have diarrhea or vomiting. If you experience dizziness or lightheadedness, lie down until the symptoms go away and try getting up more slowly. If this continues, or if you faint, contact your physician.

Systemic lupus erythematosus: People with systemic lupus erythematosus should be monitored by their physician while taking chlorthalidone, as it may worsen this condition.

Vision problems: Although this is uncommon, chlorthalidone can cause sudden changes in vision, blurred vision, or increased pressure in the eyes. If you experience blurred vision, eye pain or sudden nearsightedness, contact your physician immediately.

Pregnancy: Azilsartan, like other medications in this class, can cause severe harm and possibly death of the developing baby if it is taken during pregnancy. This medication should not be used during pregnancy. If you become pregnant while taking this medication, contact your physician immediately.

Breast-feeding: It isn’t known if azilsartan-chlorthalidone passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your physician about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children.

Seniors: Seniors may be more sensitive to the effects of this medication. It may be necessary to take a lower dose.

Drug-Drug interaction of the medication

There may be an interaction between azilsartan-chlorthalidone and any of the following:

  • aclidinium
  • alcohol
  • aldesleukin
  • aliskiren
  • allopurinol
  • alpha blockers (e.g., alfuzosin, doxazosin, tamsulosin)
  • alpha agonists (e.g., clonidine, methyldopa)
  • amifostine
  • amphetamines (e.g., dextroamphetamine, methamphetamine)
  • angiotensin-converting enzyme inhibitors (ACEIs; e.g., captopril, ramipril)
  • other angiotensin receptor blockers (ARBs; e.g., irbesartan, losartan)
  • anti-diabetic agents (e.g., glyburide, insulin, metformin, rosiglitazone)
  • antihistamines (e.g,. cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine)
  • antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
  • atropine
  • azelastine
  • barbiturates (e.g., butalbital, phenobarbital)
  • belladonna
  • benztropine
  • beta-2 agonists (e.g., formoterol, salbutamol, salmeterol, terbutaline)
  • beta-blockers (e.g., atenolol, metoprolol, propranolol)
  • brimonidine
  • calcium channel blockers (e.g., amlodipine, diltiazem, nicardipine, verapamil)
  • calcium supplements
  • carbamazepine
  • cholestyramine
  • ciprofloxacin
  • clonidine
  • colestipol
  • corticosteroids, including inhaled (e.g., budesonide, dexamethasone, fluticasone, prednisone)
  • cyclobenzaprine
  • cyclophosphamide
  • cyclosporine
  • digoxin
  • dipyridamole
  • disopyramide
  • diuretics (water pills; e.g., amiloride, furosemide, hydrochlorothiazide)
  • dofetilide
  • drospirenone
  • flavoxate
  • ginger
  • ginseng
  • guanfacine
  • glycopyrrolate
  • heparin
  • hydralazine
  • ipratropium
  • ketotifen
  • levodopa
  • lithium
  • low-molecular-weight heparins (e.g., dalteparin, enoxaparin, tinzaparin)
  • methylphenidate
  • minoxidil
  • monoamine oxidase inhibitors (MAOIs; e.g., moclobemide, phenelzine, rasagiline, selegiline, tranylcypromine)
  • multivitamins
  • nitrates (e.g., nitroglycerin, isosorbide dinitrate, isosorbide mononitrate)
  • non-steroidal anti-inflammatory medications (NSAIDs; e.g., celecoxib, ibuprofen, naproxen)
  • opioid (narcotic) pain relievers (e.g., codeine, fentanyl, morphine, oxycodone)
  • orphenadrine
  • oxcarbazepine
  • oxybutynin
  • pentoxifylline
  • phosphodiesterase-5 inhibitors (e.g., sildenafil, tadalafil, vardenafil)
  • potassium supplements
  • quinine
  • riociguat
  • scopolamine
  • selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, duloxetine, fluoxetine, paroxetine, sertraline)
  • sodium phosphates
  • tiotropium
  • tolterodine
  • tolvaptan
  • topiramate
  • tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, trimipramine)
  • trimethoprim
  • umeclidinium
  • vitamin D (e.g., calcitriol, cholecalciferol)
  • yohimbine

If you are taking any of these medications, talk to your physician or pharmacist. Depending on your specific circumstances, your physician may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications doesn’t always mean that you must stop taking one of them. talk to your physician about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your physician or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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