Edarbi How it works, Uses, Side Effects, Interactions
Today’s Article about Edarbi How it works, Uses, Side Effects, Interactions
Benefits of using this medication
Azilsartan belongs to a family of medicines known as angiotensin II receptor blockers. It is used alone or with other medications to lower mild-to-moderate high blood pressure.
Angiotensin II is a chemical that the body releases to cause the constriction of blood vessels. Azilsartan blocks the action of angiotensin II, resulting in the relaxation of the blood vessels. This relaxation causes the blood pressure to decrease. Azilsartan can be used alone or in combination with thiazide diuretics (water pills; e.g., hydrochlorothiazide) or calcium channel blockers (e.g., diltiazem, nifedipine, verapamil).
Your physician may have suggested this medication for conditions other than those listed in this article. If you have not discussed this with your physician or aren’t sure why you are taking this medication, talk to your physician. Do not stop taking this medication without consulting your physician.
dosage forms of medication
Each white to nearly white round tablet debossed “ASL” on one side and “40” on the other contains 42.68 mg of azilsartan medoxomil potassium, which is equivalent to 40 mg of azilsartan medoxomil. Nonmedicinal ingredients: mannitol, fumaric acid, sodium hydroxide, hydroxypropyl cellulose, croscarmellose sodium, microcrystalline cellulose, and magnesium stearate.
Each white to nearly white round tablet debossed “ASL” on one side and “80” on the other contains 85.36 mg of azilsartan medoxomil potassium, which is equivalent to 80 mg of azilsartan medoxomil. Nonmedicinal ingredients: mannitol, fumaric acid, sodium hydroxide, hydroxypropyl cellulose, croscarmellose sodium, microcrystalline cellulose, and magnesium stearate.
dose of medication
The recommended starting dose for adults is 40 mg taken orally once daily by mouth. The dose may be increased to a maximum of 80 mg once daily if necessary to control your blood pressure.
Azilsartan may be taken with food or on an empty stomach.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your physician has recommended a dose different from the ones listed here, don’t change the way that you are taking the medication without consulting your physician.
It is important that this medication be taken exactly as prescribed by your physician. in case of missed dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you aren’t sure what to do after missing a dose, contact your physician or pharmacist for advice.
Store this medication at room temperature, in the original container. Protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Contraindications to the use of the medication
Do not take azilsartan if you:
- are allergic to azilsartan or any ingredients of the medication
- are taking aliskiren and have diabetes or moderately to severely decreased kidney function
- are or may be pregnant
- are breast-feeding
side effects of the medication
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below aren’t experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your physician.
These symptoms may occur in some patients and in this case, you should refer to your consultant. But the majority of the patients don’t suffer from any side effects, so do not stop using the medicine because of fear of in listed side effect . , .
Contact your physician if you experience these side effects and intolerable. Your pharmacist may be able to advise you on managing side effects.
- muscle pain or spasms
- trouble sleeping
Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you don’t seek medical attention.
Check with your physician as soon as possible if any of the following side effects occur:
- irregular, rapid, or pounding heart beat
- lightheadedness or dizziness when rising from a sitting or lying position
- signs of bleeding (e.g., nosebleeds, blood in urine, coughing blood, bleeding gums, unusual bruising or bleeding)
- signs of kidney problems (e.g., decreased urination, nausea, vomiting, swelling of the feet and ankles)
- signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
- signs of muscle damage (e.g., muscle pain, tenderness or weakness, or brown or discoloured urine)
- swelling of the ankles, feet or hands
- symptoms of too much potassium in the body (e.g., muscle fatigue, weakness, difficulty moving, abnormal heart rhythms, nausea)
- symptoms of a urinary tract infection (e.g., pain when urinating, urinating more often than usual, low back or flank pain)
Stop taking the medication and seek immediate medical attention if any of the following occur:
- signs of a serious allergic reaction (e.g., swelling of face or throat, hives, or difficulty breathing)
Some people may experience side effects other than those listed. Check with your physician if you notice any symptom that worries you while you are taking this medication.
precautions of the medication
Before you start using a medication, be sure to inform your physician of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Allergy: People who have had an allergic reaction to other ARBs are advised not to take azilsartan. Before you take azilsartan, inform your physician about any previous adverse reactions you have had to medications. Contact your physician at once if you experience signs of an allergic reaction such as skin rash, itching, difficulty breathing, or swelling of the face and throat.
Kidney problems: Azilsartan may affect the function of the kidneys, especially for those people who already have kidney problems. Taking diuretics (water pills) such as aliskiren or nonsteroidal anti-inflammatory drugs (NSAIDs) such as ASA (Aspirin) may further increase the risk of kidney problems. If you have reduced kidney function, kidney disease, or renal artery stenosis (narrowing of blood vessels in the kidneys), discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Liver function: Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. If you have liver problems, discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your physician may want to test your liver function regularly with blood tests while you are taking this medication.
Low blood pressure: Occasionally, a larger-than-expected decrease in blood pressure occurs after taking azilsartan. In some cases, this happens after the first dose. It is more likely to occur if you take diuretics (water pills) such as aliskiren, have a reduced salt intake, are on dialysis, or are experiencing diarrhea or vomiting. Blood pressure should be monitored more often in these situations. If you have low blood pressure, are just starting this medication or are increasing the dose, move slowly from a reclining to an upright position to reduce the risk of dizziness.
Pregnancy: Azilsartan should not be taken by pregnant women as it can cause harm to an unborn child. If you are planning to become pregnant, discuss alternative medications for blood pressure control with your physician. If you become pregnant while taking this medication, stop taking it and tell your physician at once.
Breast-feeding: It isn’t known if azilsartan passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your physician about whether you should continue breast-feeding.
Children: The safety and effectiveness of this medication have not been established for children.
Seniors: Seniors may be at increased risk of experiencing low blood pressure from this medication.
Drug-Drug interaction of the medication
There may be an interaction between azilsartan and any of the following:
- alpha blockers (e.g., alfuzosin, doxazosin, tamsulosin)
- alpha agonists (e.g., clonidine, methyldopa)
- amphetamines (e.g., dextroamphetamine, lisdexamphetamine)
- angiotensin converting enzyme inhibitors (ACEIs; e.g., captopril, lisinopril, ramipril)
- barbiturates (e.g., butalbital, pentobarbital phenobarbital)
- beta-adrenergic blockers (e.g., atenolol, propranolol, sotalol)
- calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
- certain anti-psychotics (e.g., clozapine, olanzapine, quetiapine, risperidone)
- diuretics (water pills; e.g., furosemide, hydrochlorothiazide, triamterene)
- low molecular weight heparins (e.g., dalteparin, enoxaparin, tinzaparin)mannitol
- monoamine oxidase inhibitors (MAOIs; e.g., moclobemide, phenelzine, rasagiline, selegiline, tranylcypromine)
- nitrates (e.g., nitroglycerin, isosorbide dinitrate, isosorbide mononitrate)
- non-steroidal anti-inflammatory medications (NSAIDs; e.g., diclofenac, ibuprofen, naproxen)
- other angiotensin receptor blockers (ARBs; e.g., candasartan, irbesartan, losartan)
- phosphodiesterase 5 inhibitors (e.g., sildenafil, tadalafil, vardenafil)
- potassium supplements
- sodium phosphates
If you are taking any of these medications, talk to your physician or pharmacist. Depending on your specific circumstances, your physician may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications doesn’t always mean that you must stop taking one of them. talk to your physician about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your physician or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Terms and Definitions used in this article:
side effects: The drug side effects are monitored by Clinical Trials and studies that are regularly published in scientific journals and medical conferences.
- If an adverse effect occurred during a clinical trial, whether it was relevant or irrelevant to the drug. It should be registered as a side effect.
- The medicine is not registered for use if the side-effects are dangerous or life-threating, and the approval of drug release to the Market is regulated by the World Health Organization WHO, the Food and Drug Administration of the United States FDA, EMEA and other national ministry of health.
- These symptoms may occur in some patients and in this case, you should refer to your consultant. But the majority of the patients don’t suffer from any side effects, so do not stop using the medicine because of fear of in listed side effect
Contraindications to the use of the drug:
contraindication is a condition or factor that serves as a reason to withhold a certain medical treatment due to the harm that it would cause the patient. Contraindication is the opposite of indication, which is a reason to use a certain treatment.
Therefore, you must inform your doctor of all the diseases that you suffer from and your health history in order not to be affected negatively by the use of a particular medicine and please do not stop using the medication by yourself without referring to a doctor
is a change in the action or side effects of a drug caused by concomitant administration with a food, beverage, supplement, or another drug.
There are many causes of drug interactions. For example, one drug may alter the pharmacokinetics of another. Alternatively, drug interactions may result from competition for a single receptor or signaling pathway.
- US National Library of Medicine, National Institutes of Health
- Centers for Disease Control and Prevention
- The FDA‘s website
- WHO‘s website
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