Dutasteride by Pro Doc How it works, Uses, Side Effects, Interactions
Today’s Article about Dutasteride by Pro Doc How it works, Uses, Side Effects, Interactions
Benefits of using this medication
Dutasteride belongs to a class of medications known as 5-alpha-reductase inhibitors. It is used to relieve symptoms of benign prostatic hyperplasia (BPH) in men with enlarged prostates. BPH is a noncancerous enlargement of the prostate gland that usually occurs in men after the age of 50.
This medication improves symptoms associated with BPH, such as:
- decreased urine flow
- difficulty urinating
- getting up to urinate during the night
- hesitation at the start of urination
It may take 6 months or more to see the full effects of this medication. Dutasteride reduces the likelihood of prostate surgery for men with BPH. It must be taken on a regular basis to be effective. If the medication is stopped, the prostate will start to grow again.
This medication may be available under several brands and/or in several different forms. Any brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed in this article. As well, some forms of this medication may not be used for all of the conditions discussed in this article.
Your physician may have suggested this medication for conditions other than those listed in this article. If you have not discussed this with your physician or aren’t sure why you are taking this medication, talk to your physician. Do not stop taking this medication without consulting your physician.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their physician has not prescribed it.
dosage forms of medication
Each yellow, opaque, oblong, soft gelatin capsule,marked with “DUT 0.5” imprinted with red ink along the length of body on one side of the capsule, contains dutasteride 0.5 mg. Nonmedicinal ingredients: butylated hydroxytoluene, FD&C Red No. 40 Aluminum Lake, hypromellose, glycerol, gelatin, isopropyl alcohol, mono- and di-glycerides of caprylic/capric acid, caproic acid, lauric acid, propylene glycol, titanium dioxide, and yellow ferric oxide.
dose of medication
The recommended dose of dutasteride is 0.5 mg once daily, with or without food. Swallow the capsule whole.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your physician has recommended a dose different from the ones listed here, don’t change the way that you are taking the medication without consulting your physician.
It is important to use this medication exactly as prescribed by your physician. If you miss a dose, skip the missed dose and continue on with your regular schedule. Do not take a double dose to make up for a missed one. If you aren’t sure what to do after missing a dose, contact your physician or pharmacist for advice.
Store this medication at room temperature and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Contraindications to the use of the medication
Do not take this medication if you:
- are allergic to dutasteride or any ingredients of the medication
- are allergic to medications in the same family (e.g., finasteride)
- are a woman or child
side effects of the medication
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below aren’t experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your physician.
The following side effects have been reported by at least 1% of people taking this medication. , and some may go away on their own over time.
Contact your physician if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
- breast enlargement or tenderness
- decreased sexual desire or ability
- erectile dysfunction (difficulty getting or keeping an erection)
Stop taking the medication and seek immediate medical attention if any of the following occur:
- rash, hives, or itching
- signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
- sudden chest tightness
- swelling of the eyelids, face, lips
Some people may experience side effects other than those listed. Check with your physician if you notice any symptom that worries you while you are taking this medication.
precautions of the medication
Before you start taking a medication, be sure to inform your physician of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take this medication.
Blood donation: Men taking this medication should not donate blood until at least 6 months have passed following their last dose. This is to prevent pregnant women from being exposed to dutasteride during a blood transfusion.
Liver disease: If you have liver disease or decreased liver function, discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Prostate cancer: Dutasteride may be linked to an increased risk of developing a rare type of cancer called high-grade prostate cancer. The risk of developing this cancer while taking this medication is still considered very small. Note that dutasteride isn’t approved to treat prostate cancer. If you experience worsening symptoms or symptoms that don’t improve within 6 months, discuss this with your physician. PSA test: Dutasteride can decrease PSA (prostate specific antigen) levels by up to 50%. Doctors often measure PSA levels to test for prostate cancer. PSA levels can still be measured for this purpose, but your physician will need to adjust the results in order for the test to be accurate. If you are having a PSA test, ensure your physician knows that you are taking dutasteride.
Women and children: Dutasteride is intended for use by men only. Women and children must avoid contact with the medication, as it is absorbed through the skin. If contact occurs, wash the exposed area immediately with soap and water.
Pregnancy: This medication is intended for use by men only. Women who may be pregnant must avoid touching any pills of dutaseride (even ones that aren’t leaking). Pregnant women or women who may be pregnant should not handle dutasteride because the medication can be absorbed through the skin and may cause abnormalities in the baby. If a pregnant woman accidentally comes in contact with the capsules, she should wash the contact area immediately with soap and water.
Breast-feeding: Dutasteride isn’t intended for use by women. It isn’t known if dutasteride passes into breast milk. Do not handle this medication if you are breast-feeding because the medication can be absorbed through the skin and may affect the baby.
Children: This medication isn’t intended for use by children. The safety and effectiveness of dutasteride have not been established for use by people in this age group.
Drug-Drug interaction of the medication
There may be an interaction between dutasteride and any of the following:
- “azole” antifungals (e.g., fluconazole, itraconazole, ketoconazole)
- grapefruit juice
- macrolide antibiotics (e.g., clarithromycin, erythromycin)
- milk thistle
- protease inhibitors (e.g., indinavir, ritonavir, saquinavir)
- St. John’s wort
If you are taking any of these medications, talk to your physician or pharmacist. Depending on your specific circumstances, your physician may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications doesn’t always mean that you must stop taking one of them. talk to your physician about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your physician or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Terms and Definitions used in this article:
side effects: The drug side effects are monitored by Clinical Trials and studies that are regularly published in scientific journals and medical conferences.
- If an adverse effect occurred during a clinical trial, whether it was relevant or irrelevant to the drug. It should be registered as a side effect.
- The medicine is not registered for use if the side-effects are dangerous or life-threating, and the approval of drug release to the Market is regulated by the World Health Organization WHO, the Food and Drug Administration of the United States FDA, EMEA and other national ministry of health.
- These symptoms may occur in some patients and in this case, you should refer to your consultant. But the majority of the patients don’t suffer from any side effects, so do not stop using the medicine because of fear of in listed side effect
Contraindications to the use of the drug:
contraindication is a condition or factor that serves as a reason to withhold a certain medical treatment due to the harm that it would cause the patient. Contraindication is the opposite of indication, which is a reason to use a certain treatment.
Therefore, you must inform your doctor of all the diseases that you suffer from and your health history in order not to be affected negatively by the use of a particular medicine and please do not stop using the medication by yourself without referring to a doctor
is a change in the action or side effects of a drug caused by concomitant administration with a food, beverage, supplement, or another drug.
There are many causes of drug interactions. For example, one drug may alter the pharmacokinetics of another. Alternatively, drug interactions may result from competition for a single receptor or signaling pathway.
- US National Library of Medicine, National Institutes of Health
- Centers for Disease Control and Prevention
- The FDA‘s website
- WHO‘s website
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