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Ondansetron Omega How it works, Uses, Side Effects, Interactions

Today’s Article about Ondansetron Omega How it works, Uses, Side Effects, Interactions

Benefits of using this medication

Ondansetron is classified as 5-HT3 receptor antagonists. This medication is used to prevent nausea and vomiting associated with certain types of cancer chemotherapy and radiation. It is also used to prevent and treat the nausea and vomiting that occurs after surgery. It works by reducing the effects of a naturally-occurring chemical in the body called serotonin, which causes nausea and vomiting.

This medication may be available under several brands and/or in several different dosage forms. Any brand name of this medication may not be available in all of the dosage forms or approved for all of the conditions discussed in this article. As well, some forms of this medication may not be used for all of the conditions discussed in this article.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their physician has not prescribed it.


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dosage forms of medication

Preservative free injection
Each mL of Ondansetron Omega contains 2 mg of ondansetron (as hydrochloride dihydrate). Nonmedicinal ingredients: citric acid monohydrate, sodium citrate, and sodium chloride.

With preservative injection
Each mL of Ondansetron Omega contains 2 mg of ondansetron (as hydrochloride dihydrate). Nonmedicinal ingredients: citric acid monohydrate, sodium citrate, sodium chloride, methylparaben, and propylparaben.


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dose of medication

The recommended adult dose of ondansetron for nausea and vomiting caused by chemotherapy is based on severity of the symptoms and ranges from 8 mg to 24 mg daily given in divided doses.

Doses for children are based on body size. The recommended dose for children is 3 to 5 mg per square metre of body surface area and will be calculated by your physician.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your physician has recommended a dose different from the one given here, don’t change the way that you are taking the medication without consulting your physician.

Ondansetron should be taken ½ to 1 hour before chemotherapy treatment. After this first dose, it should be taken every 8 to 12 hours for up to 5 days.

Use an oral syringe to measure each dose of the liquid, as it gives a more accurate measurement than household teaspoons.

The recommended adult dose of ondansetron to treat and prevent nausea and vomiting caused by radiation therapy is 8 mg taken by mouth, 1 to 2 hours before treatment, and then every 8 hours for up to 5 days after treatment.

The recommended adult dose of ondansetron to prevent nausea and vomiting caused by surgery is 16 mg taken by mouth, 1 hour before anesthesia. Alternatively a dose of 4 mg may be given by intravenous (into a vein) injection at the time of surgery. After surgery, a single dose of 4 mg of ondansetron may be given by intravenous injection to treat nausea or vomiting.

Ondansetron isn’t effective for treating or preventing nausea and vomiting caused by motion.

It is important to take this medication exactly as prescribed by your physician. in case of missed dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you aren’t sure what to do after missing a dose, contact your physician or pharmacist for advice.

Store all forms of this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Contraindications to the use of the medication

Do not take this medication if you:

  • are allergic to ondansetron or any ingredients of the medication
  • are taking the medication apomorphine

side effects of the medication

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below aren’t experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your physician.

These symptoms may occur in some patients and in this case, you should refer to your consultant. But the majority of the patients don’t suffer from any side effects, so do not stop using the medicine because of fear of in listed side effect 1% of people taking this medication. , and some may go away on their own over time.

Contact your physician if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • constipation
  • flushing or feeling warm
  • low blood pressure
  • unusual tiredness or weakness

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you don’t seek medical attention.

Check with your physician as soon as possible if any of the following side effects occur:

  • blurred vision
  • difficulty moving or abnormal body movement
  • dizziness
  • pain, redness, or burning at place of injection
  • rapid pounding heartbeat

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • seizures
  • signs of a serious allergic reaction (i.e., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
  • signs of heart problems (e.g., fast, irregular heartbeat or pulse, chest pain, sudden weight gain,  difficulty breathing, leg swelling)
  • signs of serotonin syndrome (e.g., agitation, confusion, mood changes, decreased coordination, hallucinations, fever, sweating)
  • signs of a severe skin reaction (e.g., a rash combined with fever or discomfort, a rash covering a large area of the body, a rash that spreads quickly, blistering, peeling)
  • temporary blindness

Some people may experience side effects other than those listed. Check with your physician if you notice any symptom that worries you while you are taking this medication.

precautions of the medication

Before you start using a medication, be sure to inform your physician of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

HEALTH CANADA ADVISORY

June 12, 2014

Health Canada has issued new information concerning the use of Zofran (ondansetron). To read the full report, visit Health Canada’s website at www.hc-sc.gc.ca.

Allergy: People who have had an allergic reaction to dolasetron or granisetron are advised not to take ondansetron. Before you take ondansetron, inform your physician about any previous adverse reactions you have had to medications. Contact your physician at once if you experience signs of an allergic reaction such as skin rash, itching, difficulty breathing, or swelling of the face and throat.

Abnormal heart rhythms: Very rarely, ondansetron can affect the heart’s electrical activity and cause an irregular heartbeat. This is more likely to happen with the injectable form of ondansetron. Certain medications (e.g., sotalol, quinidine, thioridazine, chlorpromazine, droperidol, pimozide, gatifloxacin, moxifloxacin, mefloquine, pentamidine, arsenic trioxide, dolasetron mesylate, probucol, tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation, and should not be used in combination with ondansetron. You are more at risk for this type of abnormal heart rhythm and its complications if you:

  • are female
  • are older than 65 years of age
  • have a family history of sudden cardiac death
  • have a history of heart disease or abnormal heart rhythms
  • have a slow heart rate
  • have congenital prolongation of the QT interval
  • have diabetes
  • have had a stroke
  • have low potassium, magnesium, or calcium levels
  • have nutritional deficiencies

If you have heart disease and abnormal heart rhythms, or are taking certain medications (e.g., verapamil, atazanavir), discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your physician may monitor your heart rate using a test called an electrocardiogram (ECG) while you are using this medication.

Liver function: Ondansetron is broken down and removed from the body by the liver. Decreased liver function slows down the removal of the medication from the body and increases the risk of side effects from ondansetron. If you have liver disease or reduced liver function, discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Motion sickness: Ondansetron isn’t effective for the treatment of motion sickness.

Neuroleptic malignant syndrome (NMS): Ondansetron, like other similar medications, can cause a potentially fatal syndrome known as neuroleptic malignant syndrome (NMS). If you notice the symptoms of NMS such as high fever, muscle stiffness, confusion or loss of consciousness, sweating, racing or irregular heartbeat, or fainting, get immediate medical attention.

Phenylketonuria: People with phenylketonuria (lacking the enzyme needed to break down phenylalanine) should take forms of ondansetron other than oral dissolving tablets (ODT). The ODT form of ondansetron contains aspartame, an ingredient that cannot be broken down in the body by people who have phenylketonuria.

Serotonin Syndrome: Severe reactions are possible when ondansetron is combined with other medications that act on serotonin, such as tricyclic antidepressants and serotonin reuptake inhibitors, medications used to treat depression. These combinations must be avoided. Symptoms of a reaction may include muscle rigidity and spasms, difficulty moving, changes in mental state including delirium and agitation. Coma and death are possible.

Pregnancy: The safety of ondansetron for use by pregnant women has not been established. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your physician immediately.

Breast-feeding: It isn’t known if ondansetron passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your physician about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication to treat nausea and vomiting caused by chemotherapy have not been established for children under 3 years of age. The safety and effectiveness of using this medication to treat nausea and vomiting caused by radiation or surgery have not been determined for children less than 18 years of age. Its use by this age group isn’t recommended.

Seniors: The safety and effectiveness of using this medication by people 65 years or older to treat nausea and vomiting caused by surgery have not been established. Seniors may be at an increased risk of developing irregular heart beat with ondansetron, particularly the injectable form. Talk to your physician about any concerns you may have.

Drug-Drug interaction of the medication

There may be an interaction between ondansetron and any of the following:

  • abiraterone
  • alpha blockers (e.g., alfuzosin, doxazosin, tamsulosin)
  • amantadine
  • amiodarone
  • anti-psychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzepine, quetiapine, risperidone)
  • apomorphine
  • aripiprazole
  • asenapine
  • atorvastatin
  • “azole” antifungals (e.g., itraconazole, ketoconazole, voriconazole)
  • barbiturates (e.g., pentobarbital, phenobarbital)
  • bedaquiline
  • bosentan
  • carbamazepine
  • carvedilol
  • chloral hydrate
  • chloroquine
  • cisapride
  • dexamethasone (systemic)
  • diphenhydramine
  • disopyramide
  • doxorubicin
  • dronedarone
  • famotidine
  • flecainide
  • formoterol
  • galantamine
  • HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delaviridine, efavirenz, etravirine, nevirapine)
  • HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
  • indapamide
  • lithium
  • macrolide antibiotics (e.g., clarithromycin, erythromycin)
  • maprotiline
  • mefloquine
  • methadone
  • mifepristone
  • nefazodone
  • nicardipine
  • octreotide
  • oxcarbazepine
  • oxytocin
  • peginterferon Alfa-2b
  • pentamidine
  • phenytoin
  • pimozide
  • primidone
  • procainamide
  • progesterone
  • propafenone
  • propranolol
  • quinidine
  • quinine
  • quinolone antibiotics (e.g., ciprofloxacin, norfloxacin, ofloxacin)
  • rifabutin
  • rifampin
  • romidepsin
  • St. John’s wort
  • selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, duloxetine, fluoxetine, paroxetine, sertraline)
  • serotonin/norepinephrine reuptake inhibitors (SNRIs; e.g., desvenlafaxine, duloxetine, venlafaxine)
  • other serotonin antagonist antiemetics (e.g., dolasetron, granisetron)
  • sotalol
  • sulfamethoxazole
  • tacrolimus
  • tamoxifen
  • tapentadol
  • tenofovir
  • tetrabenazine
  • tocilizumab
  • tramadol
  • trazodone
  • tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, trimipramine)
  • trimethoprim
  • tyrosine kinase inhibitors (e.g., dabrafenib, imatinib, nilotinib, sunitinib)
  • vardenafil
  • venlafaxine
  • verapamil
  • vinblastine
  • vorinostat

If you are taking any of these medications, talk to your physician or pharmacist. Depending on your specific circumstances, your physician may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications doesn’t always mean that you must stop taking one of them. talk to your physician about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your physician or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

. we discussed today Ondansetron-Omega

Terms and Definitions used in this article:

side effects: The drug side effects are monitored by Clinical Trials and studies that are regularly published in scientific journals and medical conferences.

    • If an adverse effect occurred during a clinical trial, whether it was relevant or irrelevant to the drug. It should be registered as a side effect.
    • The medicine is not registered for use if the side-effects are dangerous or life-threating, and the approval of drug release to the Market is regulated by the World Health Organization WHO, the Food and Drug Administration of the United States FDA, EMEA and other national ministry of health.
    • These symptoms may occur in some patients and in this case, you should refer to your consultant. But the majority of the patients don’t suffer from any side effects, so do not stop using the medicine because of fear of in listed side effect

Contraindications to the use of the drug:

contraindication is a condition or factor that serves as a reason to withhold a certain medical treatment due to the harm that it would cause the patient. Contraindication is the opposite of indication, which is a reason to use a certain treatment.

Therefore, you must inform your doctor of all the diseases that you suffer from and your health history in order not to be affected negatively by the use of a particular medicine and please do not stop using the medication by yourself without referring to a doctor

Drug interactions:

is a change in the action or side effects of a drug caused by concomitant administration with a food, beverage, supplement, or another drug.

There are many causes of drug interactions. For example, one drug may alter the pharmacokinetics of another. Alternatively, drug interactions may result from competition for a single receptor or signaling pathway.

references:

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