Benefits of using this medication

Rilpivirine belongs to a class of medications called antiretroviral agents and more specifically, to the class of medications called non-nucleoside reverse transcriptase inhibitors (NNRTIs). Reverse transcriptase is an enzyme that is needed by human immunodeficiency virus (HIV) for reproduction. Rilpivirine blocks the action of this enzyme.

When used in combination with other antiretroviral medications, rilpirivine treats HIV infection and helps prevent the HIV from reproducing. HIV is the virus responsible for acquired immune deficiency syndrome (AIDS). HIV infection destroys CD4 (T) cells, which are important to the immune system. The immune system helps fight infections. When used with other antiretroviral medications, rilpivirine reduces the amount of HIV in the blood and increases CD4 (T) cell counts.

Your physician may have suggested this medication for conditions other than those listed in this article. If you have not discussed this with your physician or aren’t sure why you are taking this medication, talk to your physician. Do not stop taking this medication without consulting your physician.

dosage forms of medication

Each white-to-off-white, film-coated, round, biconvex tablet, engraved with “TMC” on one side and “25” on the other side, contains 25 mg of rilpivirine as rilpivirine hydrochloride. Nonmedicinal ingredients: croscarmellose sodium, magnesium stearate, lactose monohydrate, povidone K30, polysorbate 20, and silicified microcrystalline cellulose; tablet coating: hypromellose 2910 6 mPa.s, lactose monohydrate, polyethylene glycol 3000, titanium dioxide, and triacetin.

dose of medication

The recommended dose of rilpivirine is one 25 mg tablet taken once daily. This medication must be taken with a meal to allow your body to absorb as much of the medication as possible. Swallow the tablet whole with water.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your physician has recommended a dose different from the ones listed here, don’t change the way that you are taking the medication without consulting your physician.

It is important to take this medication exactly as prescribed by your physician. The effectiveness of the medication depends on there being the right amount of this medication in the bloodstream.

in case of missed dose within 12 hours of the usual time you take the dose, take it as soon as possible with a meal, and then continue with your regular schedule. in case of missed dose by more than 12 hours, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you aren’t sure what to do after missing a dose, contact your physician or pharmacist for advice.

Store this medication at room temperature, in its tightly closed, original container. Protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Contraindications to the use of the medication

Do not take this medication if you:

  • are allergic to rilpivirine or any ingredients of this medication
  • are taking any of the following medications:
    • carbamazepine
    • dexamethasone (more than one dose)
    • oxcarbazepine
    • phenobarbital
    • phenytoin
    • proton pump inhibitors (esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole)
    • rifampin
    • rifapentine
    • St. John’s wort

Do not give this medication to children under 12 years of age.

side effects of the medication

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below aren’t experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your physician.

These symptoms may occur in some patients and in this case, you should refer to your consultant. But the majority of the patients don’t suffer from any side effects, so do not stop using the medicine because of fear of in listed side effect . , .

Contact your physician if you experience these side effects and intolerable. Your pharmacist may be able to advise you on managing side effects.

  • decreased appetite
  • diarrhea
  • dizziness
  • drowsiness
  • fatigue
  • headache
  • nausea
  • stomach pain
  • trouble sleeping
  • unusual dreams
  • vomiting

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you don’t seek medical attention.

Check with your physician as soon as possible if any of the following side effects occur:

  • changes in fat distribution (increased fat in the upper back and neck, breasts, and trunk; and loss of fat from the arms, legs, and face)
  • signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
  • skin rash
  • symptoms of immune system changes (e.g., fever, joint or muscle pain, redness, rash, swelling, or fatigue)
  • symptoms of liver problems (e.g., abdominal pain, persistent vomiting, feeling unwell, fever, itching, yellowing of the skin and eyes, dark urine),

Seek immediate medical attention if any of the following occur:

  • signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
  • signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort
  • symptoms of heart rhythm disturbance, such as abnormal heart rhythms (e.g., fast or slow heart rate, palpitations), fainting, or seizures

Some people may experience side effects other than those listed. Check with your physician if you notice any symptom that worries you while you are taking this medication.

precautions of the medication

Before you start using a medication, be sure to inform your physician of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Abnormal heart rhythms: This medication can cause abnormal heart rhythms. Certain medications (e.g., sotalol, quinidine, thioridazine, chlorpromazine, pimozide, gatifloxacin, moxifloxacin, mefloquine, tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation, and should not be used in combination with rilpivirine.

If you have heart disease and abnormal heart rhythms, or are taking certain medications that can affect heart rhythm, discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Depression: Antiretroviral medications have been known to cause mood swings and symptoms of depression. If you have depression or a history of depression, discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

If you experience symptoms of depression such as poor concentration, changes in weight, changes in sleep, decreased interest in activities, or notice them in a family member who is taking this medication contact your physician as soon as possible.

Fat redistribution: Over time, this medication may change how fat is distributed in your body and may change your body shape. You may notice increased fat in the upper back and neck, breast, around the back, chest, and stomach area; or loss of fat from the legs, arms, and face. The long-term effects of this aren’t known.

Galactose intolerance: Rilpivirine contains lactose. If you have hereditary galactose intolerance you should not take this medication.

Hepatitis B: The safe use of this medication for people who are also infected with hepatitis B has not been established. Your physician may test you for hepatitis B infection before starting you on this medication. If this medication is used to treat HIV and you also have hepatitis B, the hepatitis B may become worse. If you have hepatitis B, discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Hypersensitivity syndrome: A severe allergic reaction called hypersensitivity syndrome can occur with the use of rilpivirine. This reaction involves a number of organs in the body and may be fatal if not treated quickly. Stop taking the medication and get immediate medical attention if you have symptoms of a severe allergic reaction, including fever, swollen glands, yellowing of the skin or eyes, or flu-like symptoms with skin rash or blistering.

Immune reconstitution syndrome: This medication may cause immune reconstitution syndrome, where signs and symptoms of inflammation from previous infections appear. These symptoms occur soon after starting anti-HIV medication and can vary. They are thought to occur as a result of the immune system improving and being able to fight infections that have been present without symptoms (such as pneumonia, herpes or tuberculosis). Report any new symptoms to your physician immediately.

Kidney function: If you have reduced kidney function, discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Liver function: Rilpivirine is largely removed from the body by the liver and may cause liver problems. Decreased liver function may cause this medication to build up in the body, causing increased side effects. If you have liver disease or decreased liver function, discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

This medication should not be used by people with severely reduced liver function.

If you experience symptoms of liver problems (e.g., abdominal pain, persistent vomiting, feeling unwell, fever, itching, yellowing of the skin and eyes, dark urine), contact your physician immediately.

Stopping the medication: If you stop taking this medication, your HIV infection could get worse. Take the medication exactly as prescribed by your doctor, and don’t stop taking the medication without checking with your physician first.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your physician immediately.

Breast-feeding: It isn’t known if rilpivirine passes into breast milk. Women who have HIV infection should not breast-feed because of the risk of passing HIV to a baby who doesn’t have the infection.

Children: The safety and effectiveness of using this medication have not been established for children less than 12 years of age or weighing less than 35 kg.

Seniors: The effects of this medication on seniors have not been well studied. It is likely that people over the age of 65 will experience more side effects and should report any unusual effects to their physician as soon as possible.

Drug-Drug interaction of the medication

There may be an interaction between rilpivirine and any of the following:

  • abiraterone acetate
  • alfuzosin
  • amiodarone
  • amphotericin B
  • antacids (e.g., aluminum hydroxide, calcium carbonate)
  • antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzepine, quetiapine, risperidone)
  • aprepitant
  • “azole” antibiotics (e.g., itraconazole, ketoconazole, voriconazole)
  • bicalutamide
  • boceprevir
  • bosentan
  • buprenorphine
  • calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
  • chloroquine
  • corticosteroids (high dose; hydrocortisone, prednisone)
  • conivaptan
  • cyclosporine
  • deferasirox
  • degarelix
  • desipramine
  • dexamethasone
  • didanosine
  • disopyramide
  • disopyramide
  • dofetilide
  • domperidone
  • dronedarone
  • enzalutamide
  • flecainide
  • grapefruit or grapefruit juice
  • H2 antagonists (e.g., cimetidine, famotidine, ranitidine)
  • hepatitis C antiviral combinations (e.g., ombitasvir – paritaprevir – ritonavir – dasabuvir, ombitasvir – paritaprevir – ritonavir)
  • HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delavirdine, efavirenz, etravirine, nevirapine)
  • HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
  • lomitapide
  • macrolide antibiotics (e.g., clarithromycin, erythromycin)
  • methadone
  • mifepristone
  • mitotane
  • modafinil
  • nefazodone
  • pimozide
  • primaquine
  • procainamide
  • protein kinase inhbitors (e.g., lapatinib, pazopanib, sunitinib)
  • proton pump inhibitors (e.g., esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole)
  • rifabutin
  • rifampin
  • rifapentine
  • quinidine
  • quinine
  • quinolone antibiotics (e.g., ciprofloxacin, ofloxacin)
  • St. John’s wort
  • seizure medications (e.g., carbamazepine, phenobarbital, phenytoin, oxcarbazepine)
  • serotonin antagonists (anti-emetic medications; e.g., granisetron, ondansetron)
  • sertraline
  • sotalol
  • tetrabenazine
  • tocilizumab
  • trazodone

If you are taking any of these medications, talk to your physician or pharmacist. Depending on your specific circumstances, your physician may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications doesn’t always mean that you must stop taking one of them. talk to your physician about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your physician or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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