Benefits of using this medication

Memantine belongs to the group of medications known as NMDA receptor antagonists. It is used alone or with other medications to treat people with moderate-to-severe Alzheimer’s disease. Memantine doesn’t cure Alzheimer’s disease, but it is used to decrease the symptoms. It works in the brain to block the effect of some chemicals that cause symptoms of Alzheimer’s disease such as decreased memory and other mental functions.

This medication may be available under several brands and/or in several different dosage forms. Any brand name of this medication may not be available in all of the dosage forms or approved for all of the conditions discussed in this article. As well, some forms of this medication may not be used for all of the conditions discussed in this article.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their physician has not prescribed it.

dosage forms of medication

Each white-to-off-white, centrally-tapered, oblong, biconvex, film-coated tablet with a single break line on both sides contains memantine hydrochloride 10 mg. Nonmedicinal ingredients: colloidal anhydrous silica, lactose monohydrate, magnesium stearate, methacrylic acid-ethyl acrylate copolymer, microcrystalline cellulose, polysorbate 80, simethicone emulsion, sodium lauryl sulfate, talc, and triacetin.

dose of medication

The usual starting dose of memantine is 5 mg once daily. This dose is gradually increased, usually over a one-month period, to 10 mg twice daily. By gradually increasing the dose, the side effects of this medication are less severe.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your physician has recommended a dose different from the ones listed here, don’t change the way that you are taking the medication without consulting your physician.

Memantine tablets can be taken with or without food. The tablets should be swallowed whole with a glass of water and should not be chewed.

It is important to take this medication exactly as prescribed by your physician. in case of missed dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your physician or pharmacist for advice.

Store this medication at room temperature in a dry place and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Contraindications to the use of the medication

Do not take this medication if you are allergic to memantine or any ingredients of the medication.

side effects of the medication

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below aren’t experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your physician.

These symptoms may occur in some patients and in this case, you should refer to your consultant. But the majority of the patients don’t suffer from any side effects, so do not stop using the medicine because of fear of in listed side effect 1% of people taking this medication. , and some may go away on their own over time.

Contact your physician if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • constipation
  • dizziness
  • drowsiness
  • fatigue
  • headache
  • loss of appetite
  • trouble sleeping
  • vomiting

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you don’t seek medical attention.

Check with your physician as soon as possible if any of the following side effects occur:

  • behavior changes (e.g., aggression, rage, agitation, anxiety, paranoia)
  • change in frequency of urination
  • confusion
  • change in balance and coordination especially when walking
  • fungal infection
  • hallucinations (seeing, hearing, or feeling things that aren’t actually there)
  • high blood pressure
  • signs of a blood clot in the arm or leg (tenderness, pain, swelling, warmth, or redness in the arm or leg) or lungs (difficulty breathing, sharp chest pain that is worst when breathing in, coughing, coughing up blood, sweating, or passing out)
  • signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
  • signs of heart failure (e.g., decreased heart rate, difficulty breathing, build up of fluid in the legs and ankles)
  • signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
  • signs of pancreatitis (e.g., abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, swollen abdomen)
  • trouble walking
  • vision changes

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • seizures
  • signs of a severe allergic reaction (hives; difficulty breathing; swelling of the mouth, lips, or throat)
  • signs of a severe skin reaction (e.g., blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort)

Some people may experience side effects other than those listed. Check with your physician if you notice any symptom that worries you while you are taking this medication.

precautions of the medication

Before you start using a medication, be sure to inform your physician of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Eyes: Memantine may build up in the tear fluid and contribute to changes in the eyes and possible changes in vision. People taking memantine should have regular check-ups from their eye physician. If you notice any changes to your vision, contact your physician as soon as possible.

Heart disease: Memantine may cause increased blood pressure, slowed heartbeat and occasionally, heart failure. If you have heart problems, discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Kidney function: The kidneys remove mematadine from the body. When the kidneys aren’t working properly, the medication can build up in the body and cause side effects. Memantine isn’t recommended for people with severe kidney disease.

If you have reduced kidney function or moderate kidney disease you may need a lower dose of memantine. Discuss with your physician how this medication may affect your medical condition and whether any special monitoring is needed.

Liver function: The safety of memantine when given to someone with severely reduced liver function has not been studied and isn’t recommended. If you have reduced liver function or liver disease, discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Reduced elimination from the body: The elimination of memantine from the body can be reduced in certain situations. These include changing from a normal diet to a strict vegetarian diet, taking certain medications (e.g., sodium bicarbonate, acetazolamide), having a kidney condition called renal tubular acidosis, or having a urinary tract infection. Your physician will monitor your condition closely in these situations.

Seizures: Memantine has not been studied for use by people who have seizure disorders (such as epilepsy). If you have a history of seizure disorder, discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your physician immediately.

Breast-feeding: It isn’t known if memantine passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your physician about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children.

Seniors: There is limited information about the safety of memantine for people over the age of 85.

Drug-Drug interaction of the medication

There may be an interaction between memantine and any of the following:

  • amantidine
  • anticholinergic medications (e.g., atropine, hyoscyamine)
  • bupropion
  • carbonic anhydrase inhibitors (e.g., acetazolamide, topiramate)
  • cimetidine
  • dextromethorphan
  • dopamine agonists (e.g., bromocriptine, pergolide, pramipexole, ropinirole)
  • hydrochlorothiazide
  • ketamine
  • levodopa
  • nicotine
  • quinidine
  • ranitidine
  • sodium bicarbonate
  • triamterene
  • trimethoprim
  • warfarin

If you are taking any of these medications, talk to your physician or pharmacist. Depending on your specific circumstances, your physician may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications doesn’t always mean that you must stop taking one of them. talk to your physician about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your physician or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications.

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